The 2025 Cancer Genetics and Epigenetics GRC will showcase and delve into a spectrum of leading-edge topics integral to cancer genetics and epigenetics, inclusive of emerging (epi)-genomics engineering technologies; advancements in cancer epitranscriptomics, spatial epigenomics & tumor microenvironment epigenomic dependencies; breakthroughs in translational cancer epigenetic therapy; latest developments in genetics & epigenetics informed cancer drivers; forefront discoveries in epigenomic plasticity & tumor evolution. As these diverse topics take center stage, the conference promises to provide a comprehensive perspective on cancer genetics and epigenetics to inspire the next wave of innovations. Beyond the stimulating talks of invited speakers, there will be additional talks selected from the submitted abstracts as well as one-minute “poster preview” talks. Furthermore, the conference will incorporate designated time for interactive poster presentation sessions, mentorship and social events providing ample opportunities for scientists from across all career stages to network and mingle. This intentional design aims to foster an inclusive community-building environment, drawing interest from a broad spectrum of researchers, and to serve as a nexus for global collaboration and knowledge exchange.